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Intestinal viral infection in cats commonly causes inflammation of the intestinal lining, stomach upset, and diarrhea. In some cases, diarrhea may be severe enough to cause life-threatening dehydration. If left untreated, certain virus strains can develop into feline infectious peritonitis, which may be fatal. Viral pathogens which are responsible for gastrointestinal infections in cats are feline panleukopenia virus (FPV), feline enteric coronavirus (FeCoV), and feline leukemia virus (FeLV), although various viral agents including astrovirus, adenovirus, rotavirus, and vesiviruses (feline calicivirus, FCV). Although current vaccines do not prevent infection in all cases, they significantly decrease the severity of disease and the shedding of virus. This is beneficial to other susceptible cats, particularly those living with the cat being vaccinated.
Figure 1. FCoV structure (Jaimes, et al., 2018).
Feline Gastrointestinal Virus VN Kit Development
All cats are vulnerable to gastrointestinal viral infection, but particular breeds are more likely to get the feline panleukopenia virus and have a higher risk of developing a serious form of gastrointestinal disease. The viral neutralization (VN) test detects antibodies capable of neutralizing the infectivity of the virus, and has become a common method for identifying subgroup-specific antibodies against feline gastrointestinal diseases. The premise behind neutralization tests is that poisons or viruses bioactivities are decreased when antibodies bind to them. This technique can be used to detect antibodies, diagnose diseases (by using specific immunosera), or locate their poisons (with defined pathogens). The ability to precisely assess serum samples is one benefit of virus neutralization methods.
BioVenic is a supplier of biological reagents and kits, and has been developing diagnostic reagents for animal viruses for many years. Our goal is to be a great company that improves the health and well-being of pets and livestock. We have a professional team with extensive experience in veterinary diagnostics and reagent development, and we can offer a variety of customized viral neutralization (VN) kits for the detection of feline gastrointestinal virus. If you have any queries, please feel free to contact us. We will provide you with high-quality products and services.
Feline Gastrointestinal Virus VN Kits We Can Provide
| Feline panleukopenia virus VN kit | Feline enteric coronavirus VN kit | Feline leukemia virus VN kit |
| Feline astrovirus VN kit | Other VN kits you need |
Workflow of Feline Gastrointestinal Virus VN Kit Development
| Workflow | Details |
| Source of virus | Live virus strains and characterized feline enteric coronavirus strains were obtained. |
| Collection of samples | Blood samples were obtained from industrial breeding firms. |
| VN assay optimization | For the optimal neutralization of homologous antigen and antibody under controlled conditions, variables were tuned during the investigation. |
| Centrifugation operation | A suspension of the antigen and the antiserum was centrifuged for five minutes. The air sac aperture was used to inject supernatant. |
| Control measures | Serum samples were obtained and were examined for relevant viral exposure. |
Delivery
- A series of VN kits for feline gastrointestinal viruses
- Report on product inspection quality
- Other experimental data you need
Our Advantages
- High specificity and high sensitivity
- Viral pathogens or their toxins can be detected
- High throughput assessment
- Detect the level of serological cross reactivity
References
- Jaimes, Javier A., and Gary R. Whittaker. "Feline coronavirus: Insights into viral pathogenesis based on the spike protein structure and function." Virology 517 (2018): 108-121.
- Shiba, Nozomi, et al., "Differentiation of feline coronavirus type I and II infections by virus neutralization test." Veterinary Microbiology 124.3-4 (2007): 348-352.
