Porcine Antibodies

The porcine is an even-toed hoofed mammal and is one of the most important sources of meat food in the world, with demand comparable to that of cattle. In addition, because of the many similarities between porcine and humans, they can also be used as disease models to study human disease mechanisms and to find new treatments. Therefore, it is important to study the immune response of porcine, especially the effect of common pathogens such as porcine respiratory and reproductive syndrome virus, porcine epidemic diarrhea virus, swine fever virus, porcine circovirus, Mycoplasma hyopneumoniae, Bordetella tracheoseptica on the immune system of porcine. Antibodies are widely used as diagnostic and antiviral reagents in the study of porcine immune response to improve the health status of porcine.

Figure 1. Development of whole-porcine monoclonal antibodies with potent neutralization activity against classical swine fever virus from single B cells (Dong, Haisi, et al., 2019).

Porcine Antibodies

Like mice, pigs can express five antibodies, IgA, IgD, IgE, IgM and IgG. Studies have shown that the genes encoding the heavy and light chains of porcine antibodies have 30 VH genes, 14-60 Vκ genes, two functional DH genes, one functional JH gene, two functional Jλ genes and five Jκ fragments. Compared to laboratory rodents, pigs can utilize a small number of VH genes to form >90% of the pre-immune antibody repertoire, a pattern that does not change with antigenic diversification.

Currently, there are a variety of porcine antibodies in circulation, including porcine CD marker antibodies, porcine cytokine antibodies, and porcine immunoglobulin antibodies, and so on. These antibodies are used to identify porcine immune responses caused by pathogens in order to effectively manage porcine epidemics and improve pork quality to ensure food safety.

BioVenic is a company that provides researchers with a variety of animal antibodies such as goat, bovine, porcine, and avian antibodies. We have an advanced antibody preparation platform and professional technicians. We offer you a wide range of monoclonal antibodies against porcine CD markers, porcine immunoglobulins and porcine cytokines. All of our antibodies have undergone rigorous quality testing, and they can be used with a variety of conjugates to study the immune response of pigs to pathogens. Our antibodies are suitable for a variety of detection methods including immunofluorescence, immunoprecipitation, immunohistochemistry, flow cytometry, Western blotting and ELISA. If you have any needs, please feel free to contact us. We will provide you with high-quality products to meet your research needs in the field of biological sciences.