The immune system is an important system for rabbits to perform immune response and immune function. It has the functions of identifying and eliminating antigenic foreign substances, coordinating with other systems of the body, and jointly maintaining the stability and physiological balance of the rabbit's internal environment. Rabbit cytokines are low molecular weight proteins secreted by rabbit immune cells. Normally, it plays a central role in the immune system by regulating cellular responses such as lymphocyte activation, proliferation, differentiation, survival and apoptosis, but can also lead to pathological responses under abnormal conditions.
Figure 1. The role of cytokines in T and B Cell binding.
Rabbit Cytokine Antibodies
Rabbits are used as animal models in a variety of laboratory studies, such as the study of immunoglobulin structure and function, the study of B cell development, the study of diseases such as trematodes and coccidioidomycosis, and vaccine research of parasitic and viral infections. In recent years, researchers have developed a series of antibodies against interleukins, interferons and chemokines, and used immunological detection methods such as ELISA to detect the changes in the concentration of these cytokines in rabbits after infection with viruses and certain bacteria.
The following are some cytokines in rabbits, such as IL-1α, IL-4, IL-8, IL-17A, IFNγ, etc.
| Rabbit cytokines | Description |
| IL-1α | Rabbit IL-1α is a pro-inflammatory cytokine belonging to the IL-1 superfamily. It is involved in the regulation of various immune and inflammatory responses in rabbits and is secreted by activated macrophages and monocytes. |
| IL-4 | Rabbit IL-4 is a regulatory cytokine that plays an important role in regulating rabbit B cell responses. It is expressed by monocytes, B cells and macrophages. |
| IL-8 | Rabbit IL-8 belongs to the chemokine CXC family and is secreted by various cells including macrophages, endothelial cells and epithelial cells in response to inflammation. |
| IL-13 | Rabbit IL-13 is an immunomodulatory cytokine produced by activated Th2 cells. |
| IL-17A | Rabbit IL-17A is a homodimer linked by a disulfide bond and belongs to the IL-17 family. |
| IL-21 | Rabbit IL-21 belongs to the type I cytokine family and is produced by activated T cells. |
| IFNγ | Rabbit IFNγ is the only member of the interferon type II family, mainly secreted by activated T lymphocytes in response to bacterial and viral infections. |
BioVenic is a company with a state-of-the-art antibody development platform and an R&D team that has extensive experience working in the field of molecular biology and immunology. Our researchers injected highly purified antigens into goats and chickens for repeated immunizations to produce sera-containing antibodies against rabbit cytokines and then obtained antibodies from host whole sera by affinity chromatography. All of our antibodies have undergone rigorous testing and quality control, and have the advantages of high purity and high specificity. If you have any needs, please feel free to contact us. We can provide you with high-quality rabbit cytokines antibodies.
Reference
- Espino, Ana M., and Francheska Rivera. "Quantitation of cytokine mRNA by real-time RT-PCR during a vaccination trial in a rabbit model of fascioliasis." Veterinary Parasitology 169.1-2 (2010): 82-92.
