Immunoglobulins (Ig) are glycoproteins produced by plasma cells and have two light and two heavy chains arranged in a light-heavy-heavy-light structure. It has two light chains and two heavy chains arranged in a light-heavy-heavy-light structure. Immunoglobulins make up about 20% of the proteins in plasma and have an Fc region that mediates biological functions and a Fab region that contains antigen binding sites.
Figure 1. The classes of rabbit immunoglobulins.
There are four immunoglobulin isotypes in rabbits, namely IgA, IgE, IgG and IgM. IgE, IgG and IgM have only one type, while IgA can be further subdivided into 13 subclasses.
| Immunoglobulin | Description |
| Immunoglobulin A | IgA has 2 distinct molecular structures: monomeric (serum) and dimeric (secreted). Serum IgA has a molecular weight of 160 Kd and secreted IgA (sIgA) has a molecular weight of 385 Kd. |
| Immunoglobulin E | IgE is a monomer that protects against parasitic infection and has a molecular weight of 188 Kd. |
| Immunoglobulin M | IgM is a pentamer with a molecular weight of 970 Kd. It is mainly produced in the primary immune response to infectious agents or antigens and is considered a potent lectin. |
| Immunoglobulin G | IgG is a monomer with two identical antigen-binding sites and a molecular weight of approximately 150 Kd. It is synthesized primarily in secondary immune responses to viruses, bacteria, and other pathogens. Rabbit has only one IgG subclass. |
Rabbit Immunoglobulin Antibodies
Rabbit immunoglobulins play an important role in defending against bacteria, viruses and fungi. In rabbits, the quantification of immunoglobulins and their functional studies are crucial for the immunodiagnosis of rabbit diseases. In recent years, researchers have developed a series of polyclonal or monoclonal antibodies against rabbit immunoglobulin, which have good specificity for rabbit immunoglobulin. They are suitable for use in ELISA, immunofluorescence, immunohistochemistry, flow cytometry, Western blotting, immunoprecipitation, etc.
BioVenic is a company that develops veterinary antibodies for the diagnosis of a wide range of animal diseases. We have a state-of-the-art antibody development platform, and our R&D staff has extensive experience working in the field of molecular biology and immunology. We obtain anti-rabbit Ig antibodies by introducing immunoglobulin (Ig) from rabbits into the immune system of an available host species (e.g. mouse, goat, donkey, etc.). Our antibodies contain biotin, fluorescein (FITC), horseradish peroxidase (HRP) and other couplers, and all of our antibodies have undergone rigorous testing and quality control, and have the advantages of high batch-to-batch consistency, high purity, high specificity, and low background signal. If you have any needs, please feel free to contact us. We will provide you with high-quality rabbit immunoglobulin antibodies according to your needs.
