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Feline respiratory infection is the common term for a respiratory infection caused by one or more viral agents. The most common viruses that cause upper respiratory infections in cats are feline herpesvirus type-1 (also known as feline viral rhinotracheitis or FVR) and feline calicivirus (FCV). FVR and FCV are responsible for approximately 90% of all feline upper respiratory infections. The typical upper respiratory infection involves the nose and throat, causing symptoms such as sneezing, nasal congestion, conjunctivitis (inflammation of the membranes lining the eyelids), and discharge from the nose or eyes. Young and adolescent cats are most susceptible to feline herpesvirus. To decrease the severity of the disease and the shedding of the virus, vaccination against feline herpes is recommended for all cats.
Figure 1. General structure of feline calicivirus (FCV) (Burmeister, et al., 2015).
Feline Respiratory Virus VN Kit Development
Most felines are susceptible to infection, but some breeds are more likely to contract the feline calicivirus and tend to be more prone to a severe variant of respiratory illness. Cats with upper respiratory disease, pneumonia, or oral ulcers may recover in days or weeks, while those with the severe systemic disease have a much less favorable prognosis. It is standard procedure to use the viral neutralization (VN) test to find subgroup-specific antibodies against feline respiratory disorders. The foundation of neutralization tests is the theory that when antibodies bind to toxins or viruses, their bioactivities are inhibited. This method can be applied to identify antibodies, identify diseases (using particular immunosera), or identify their toxins (with defined pathogens). One advantage of virus neutralization approaches is the capacity to precisely evaluate serum samples.
BioVenic is a supplier of biological reagents and kits, and has been developing diagnostic reagents for animal viruses for many years. Our goal is to be a great company that improves the health and well-being of pets and livestock. We have a professional team with extensive experience in veterinary diagnostics and reagent development, and we can provide you with a series of customized virus neutralization kits for the detection of feline respiratory virus based on your needs. If you have any queries, please feel free to contact us. We will provide you with high-quality products and services.
Feline Respiratory Virus VN Kits We Can Provide
| Feline calicivirus VN kit | Feline herpesvirus VN kit | Feline parainfluenza virus VN kit |
| Feline viral rhinotracheitis VN kit | Other VN kits you need |
Workflow of Feline Respiratory Virus VN Kit Development
| Workflow | Details |
| Viral source | Live virus strains and characterized feline calicivirus strains were obtained. |
| Sample collection | Blood samples were obtained from industrial breeding firms. |
| VN assay optimization | For the optimal neutralization of homologous antigen and antibody under controlled conditions, variables were tuned during the investigation. |
| Centrifugation | A suspension of the antigen and the antiserum was centrifuged for five minutes. The air sac aperture was used to inject supernatant. |
| Control measures | Serum samples were obtained and were examined for relevant viral exposure. |
Delivery
- A series of VN kits for feline respiratory viruses
- Report on product inspection quality
- Other experimental data you need
Our Advantages
- High specificity
- High throughput assessment
- Viral pathogens or their toxins can be detected
- Detect the level of serological cross reactivity
References
- Burmeister, Wim P., et al., "Structure determination of feline calicivirus virus-like particles in the context of a pseudo-octahedral arrangement." PloS One 10.3 (2015): e0119289.
- Willi, Barbara, et al., "Molecular characterization and virus neutralization patterns of severe, non-epizootic forms of feline calicivirus infections resembling virulent systemic disease in cats in Switzerland and in Liechtenstein." Veterinary Microbiology 182 (2016): 202-212.
