The goat was one of the earliest animals domesticated by humans and is a member of the bovid family. Goats are not only a major source of dairy products, meat and fur in most countries around the world, but also animal models for large ruminant infectious diseases and human diseases such as tuberculosis and chronic rheumatoid arthritis. Goats are widely bred all over the world. However, as goat breeding density increases, goats can become infected with various viral and bacterial diseases such as brucellosis, foot and mouth disease, red eye, goat arthritis encephalitis, caseous lymph nodes pneumonia, tuberculosis and rabies. The prevalence of these diseases has brought huge economic losses to the goat breeding industry. Therefore, it is crucial to develop goat antibodies for immune response studies and goat disease management.
Caprine Antibodies
In recent years, researchers have developed a series of monoclonal and polyclonal antibodies against goat cell surface markers, goat cytokines and goat immunoglobulins. Clonality is one of the important factors to consider when selecting antibodies, depending on whether the antibodies are derived from different B cells (polyclonal antibodies) or the same B cells (monoclonal antibodies). These antibodies have their own advantages and limitations.
Monoclonal antibodies are produced by a single B cell and recognize only one epitope of a single antigen. Monoclonal antibodies are highly specific for the targeted antigen epitope and have low non-specific cross-reactivity and minimal batch-to-batch variation. Polyclonal antibodies are a mixture of heterotypic antibodies, each recognizing a different epitope of the same antigen. Because polyclonal antibodies detect a range of epitopes on a protein, they have a higher risk of inter-batch variation compared to monoclonal antibodies. Polyclonal antibodies are not specific for a single epitope, they are more forgiving of small changes in antigen than monoclonal antibodies.
Depending on the purpose of the test, researchers can choose the appropriate antibody detection method, such as IHC (immunohistochemistry) and ICC (immunocytochemistry) to detect the location of antibodies, ELISA (enzyme-linked immunosorbent assay) and WB (Western blot) to detect the concentration of antibodies, and FCM (flow cytometry) for the expression of cell surface markers.
BioVenic is a supplier of diagnostic reagents for animal pathogens and has been developing antibodies for a wide range of animals such as cattle, goat, sheep and rabbits for many years. We have experienced technicians and a mature platform for sheep antibody preparation. Our researchers stimulated rabbits and mice to produce sera containing goat antibodies using high-purity goat cell surface markers, goat immunoglobulins and goat cell cytokines as antigens, and then prepared high-purity goat antibodies from the whole sera by affinity chromatography. So we can provide you with a series of goat polyclonal and monoclonal antibodies. If you have any needs, please feel free to contact us.
