Clusters of differentiation (CDs) are cell surface markers used to identify leukocytes and different leukocyte subsets. The HLDA (Human Leukocyte Differentiation Antigen) workshop held in 1982, developed the CD nomenclature, which provides a uniform nomenclature system for monoclonal antibodies (mAbs) and the cell surface molecules they recognize. In 1991, the first porcine CD workshop was held under the auspices of the IUIS Veterinary Immunology Committee. A number of porcine CD antigens were defined using human CD nomenclature guidelines. Subsequently, the second and third pig CD workshops were held, updating and refining the pig CD nomenclature.
Figure 1. The phenotype and functional status of individual subsets of porcine B cells (Šinkora, et al., 2009).
Porcine CD Marker Antibodies
In recent years, as the world population has increased, the demand for food has also increased. Pigs are the main food source worldwide and their breeding scale is expanding with the increase of population. The spread of infectious diseases in pig herds can affect the health status of pigs and even cause death, which in turn affects food safety and causes huge economic losses to the pig farming industry. Therefore, the prevention and treatment of infectious diseases in swine herds is crucial and requires a great understanding of cellular immunity in pigs. At present, researchers have developed a series of antibodies against porcine cell surface markers, such as antibodies for the study of porcine T cells: anti-pig CD3, CD4a, CD8a, CD8b and CD25, antibodies for the study of porcine dendritic cells: anti-pig CD163 and CD172a, antibodies for the study of monocytes and macrophages: anti-pig CD11R3, CD14 and CD16, antibodies for the study of endothelial cells: anti-pig CD31.
The following table shows several common porcine CD markers. Antibodies against these molecules have proven essential in biomedical research and diagnostics as well as in biotechnology.
| Type | Description |
| CD3 | CD3 is a multimeric protein complex that acts as a T cell co-receptor non-covalently bound to the T cell receptor (TCR). CD3 is a marker for porcine T cells. |
| CD4 | Porcine CD4 is a type 1 trans-membrane member of the immunoglobulin superfamily. |
| CD8 | For study the porcine T cell. |
| CD14 | Cloning and characterization of porcine CD14 showed a high degree of functional and structural conservation. |
| CD25 | CD25 is a 270 amino acid single pass type I transmembrane glycoprotein. It is low expressed on resting peripheral blood mononuclear cells. |
| CD31 | Mainly expressed by peripheral blood platelets and a small fraction of lymphocytes. |
| CD163 | CD163 is a single pass type 1 transmembrane cell surface glycoprotein expressed on cells of the monocyte/macrophage lineage. |
As a leading supplier of veterinary antibodies, BioVenic has a state-of-the-art antibody development platform and professional technical staff. We can provide you with a range of antibodies against porcine CD marker antigens. All of our antibodies have undergone rigorous testing and quality control, they are suitable for use in ELISA, immunofluorescence, immunohistology, flow cytometry, Western blotting, immunoprecipitation, etc. If you have any needs, please feel free to contact us. We will provide you with high-quality products for the diagnosis of a wide range of animal diseases.
References
- Dawson, Harry D., and Joan K. Lunney. "Porcine cluster of differentiation (CD) markers 2018 update." Research in Veterinary Science 118 (2018): 199-246.
- Šinkora, Marek, and John E. Butler. "The ontogeny of the porcine immune system." Developmental & Comparative Immunology 33.3 (2009): 273-283.
