The horse is a domesticated single-toed hoofed mammal. It belongs to the taxonomic equine family, one of the two extant subspecies of equid. With the development of the times, the main uses of horses have gradually shifted from warfare and transportation to recreation, sports and fitness, and biological product development. The development of modern horse industry plays an important role in promoting economic development. Equine infectious diseases and lentiviral diseases, such as horse piriformis, equine protozoal myelitis, and equine herpes virus, are widely prevalent around the world, causing huge economic losses to the horse industry. Therefore, the development of antibodies for equine immune response studies is important for the diagnosis of equine diseases.
Figure 1. EHV-1 infection of naïve or susceptible horses induces a variety of cytokines at the respiratory viral entry site while pre-existing mucosal IgG4/7 antibodies in protected or immune horses block EHV-1 entry into respiratory epithelial cells and prevent all down-stream effects of EHV-1 infection (Larson, et al., 2021).
Equine Antibodies
Because horses have many naturally occurring diseases with similar conditions in humans, their availability for environmental control experiments and induced disease studies makes them a valuable intermediate model between mouse studies and human clinical trials. The study of equine antibodies is critical to the control of equine diseases and the development of drugs for related diseases. Although equine antibodies have been extensively studied by researchers since the 1970s, a more comprehensive understanding of equine antibodies has only been achieved in recent years. Currently, researchers have developed a series of monoclonal and polyclonal antibodies against equine cell surface markers (e.g., CD2, CD4, CD8, CD13, etc.), equine immunoglobulins (IgM, IgD, IgA, IgE and IgG), and equine cytokines (e.g., chemokines, interferons, interleukins, etc.).
BioVenic is a supplier of biological reagents and kits, developing diagnostic reagents for animal pathogens for many years. We have a state-of-the-art antibody development platform and professional technical staff. Based on our advanced antibody development platform, we can provide you with different sizes of antibodies to detect equine cell surface markers, equine lymphokines and equine immunoglobulins to study the immune response of B cells, T cells and dendritic cells after equine infection with pathogens. All of our antibodies have undergone rigorous testing and quality control, and have the advantages of high purity and high specificity. They are suitable for a range of applications including immunoprecipitation, Western blotting, ELISA, immunohistochemistry, and flow cytometry. If you need equine antibodies to study equine immune responses and equine diseases, please feel free to contact us.
References
- Larson, Elisabeth M., and Bettina Wagner. "Viral infection and allergy–What equine immune responses can tell us about disease severity and protection." Molecular Immunology 135 (2021): 329-341.
- Wagner, Bettina. "Immunoglobulins and immunoglobulin genes of the horse." Developmental & Comparative Immunology 30.1-2 (2006): 155-164.
