Immunoglobulin (Ig) is a class of globulins with antibody activity or chemical structure similar to that of antibodies, including both secretory and membrane types. Ig has specificity and diversity. They are produced after the body is stimulated by antigens (such as pathogens), and their main function is to react with antigens to generate antigen-antibody complexes, thereby blocking the harm of pathogens to the body and making pathogens lose their pathogenic effect. However, it is also an antigenic substance for heterogeneous animals, different individuals of the same species or some lymphocyte clones in the body, which can stimulate the body to produce the corresponding antibodies, i.e. anti-Ig antibodies. Using sera containing anti-Ig antibodies (serological identification), the antigenic epitopes of immunoglobulins can be analyzed and classified into three serotypes: isotype, allotype, and idiotype.
Figure 1. Classes of immunoglobulins.
Antibodies Recognizing Equine Immunoglobulins
Over the past century, many eminent immunologists have studied equine antibodies in depth and have generated new insights into the equine humoral immune system. Studies have shown that equines have 11 immunoglobulins: IgM, IgD, IgA, IgE, and seven different IgG isotypes. Immunoglobulin (Ig) isotypes have different functions during the immune response and pathogen-specific isotypes can be used as indicators for the diagnosis and prevention of equine diseases. Since antibodies are the end product of humoral immunity, the health status of equines can be quickly assessed by detecting anti-Ig antibodies in their serum, plasma or whole blood. Researchers have developed a variety of monoclonal antibodies against various equine Igs, however, the quantification of individual isotypes requires pure isotype standards.
Rapid diagnosis of equine diseases is essential to reduce equine mortality and economic losses to the livestock industry. BioVenic, a veterinary antibody supplier, has been developing antibody reagents for many years. Our technical staff has extensive experience working in the field of veterinary diagnostics and antibody development. We are also equipped with advanced instrumentation to ensure the accuracy of our assays. So we can offer you a range of antibodies against equine immunoglobulins for rapid diagnosis of equine diseases and assessment of the overall health of the equine. If you have any needs, please feel free to contact us. We will provide you with high-quality products according to your needs, and our products are suitable for various diagnostic methods, such as ELISA, flow cytometry, immunohistology, Western blotting, etc.
