The cluster of differentiation (CD) refers to transmembrane proteins or glycoproteins found on cell membranes. In 1982, the First International Workshop and Symposium on Human Leukocyte Differentiation Antigens (HLDA) held in Paris standardized the nomenclature for these proteins. This nomenclature also applies to the chicken cluster of differentiation. Each unique CD molecule is assigned a different number, which serves as the most common cell surface marker used to distinguish different cell types. Some CD molecules can act as important cellular receptors or ligands involved in cell signaling, while some CD molecules are not involved in cell signaling but have other functions, such as cell adhesion.
Figure 1. Chicken bone marrow-derived dendritic cell (chBMDC) cultures contained clusters of major histocompatibility complex class II (MHC-II)+ cells (Van den Biggelaar, et al., 2020).
Chicken CD Marker Antibodies
In recent years, the total amount of food needed by the world has been increasing with the growth of the global population. Poultry products as cheap and easily available food have become the key to solve the food supply of the global population. Therefore, the chicken industry can bring huge economic benefits to people, and the effective detection and control of chicken infectious diseases is very important to reduce the economic losses of the chicken industry. The research on chicken immune system is the premise of detecting and controlling chicken infectious diseases. Currently, researchers have developed a series of chicken CD marker antibodies for the study of chicken immune cells (e.g., macrophages, B cells, T cells, and dendritic cells).
The following are CD molecules commonly used to develop chicken CD marker antibodies. They have been proven essential in biomedical research and diagnostics as well as in biotechnology.
| Cell Type | CD Marker | Description |
| T cell/ B cell | CD3 | CD3 is a member of the T cell receptor-associated CD3 complex. Chicken CD3 is expressed by approximately 30% of thymocytes and 70% of peripheral blood mononuclear cells. |
| CD4 | CD4 is a cell surface protein expressed by thymocytes and a subset of T cells. | |
| CD8 | Chicken CD8 is expressed on approximately 80% of thymocytes and 15% of blood mononuclear cells. | |
| CD28 | Chicken CD28 is expressed by all thymocytes and T cells. | |
| CD44 | CD44 is a marker of T cell activation, which implicated in cell migration, activation, and differentiation. | |
| CD45 | CD45 is a signal transduction protein vital for T and B cell antigen receptor-mediated activation. | |
| Macrophage and dendritic cell | CD14 | CD14 is a membrane glycoprotein and monocyte/macrophage differentiation antigen. |
| Thrombocytes | CD41/CD61 | CD41/61 is a heterodimeric cell surface protein, expressed on chicken thrombocytes and cells of the thrombocyte lineage. |
As a leading supplier of veterinary antibodies, BioVenic has a state-of-the-art antibody development platform and professional technical staff. We have developed a variety of chicken CD marker antibodies against chicken CD molecules (such as CD3, CD4, CD14, CD25, CD28, etc.), and all of our antibodies have undergone rigorous testing and quality control. If you have any needs, please feel free to contact us. We will provide you with high-quality products to study chicken immune cells and thus diagnose chicken diseases such as avian influenza.
Reference
- Van den Biggelaar, Robin HGA, et al. "In vitro chicken bone marrow-derived dendritic cells comprise subsets at different states of maturation." Frontiers in Immunology 11 (2020): 141.
