Hamster (CHO) Legumain ELISA Kit

Product Description:

Legumain is a host cell protein (HCP) generated by CHO cells during production of biotherapeutics. This process-related impurity accumulates in the extracellular space as it is released from dead CHO cells and secreted from viable cells during cell culture. Legumain, a lysosomal protease, cleaves the asparaginyl and aspartyl bonds of therapeutic monoclonal antibodies, thus compromising their integrity, stability, and efficacy.

Antibody Type:

ELISA

Reactivity:

CHO, Hamster

Host:

Chicken

Specificity/Target:

Legumain

Detection Range:

20 ng/mL - 0.3125 ng/ml

Assay Time:

170 minutes

Sample Type:

Tissue culture fluids

Storage Conditions:

2-8°C