Mouse Anti-Chicken MCAM-PE (C264)

Description:

Chicken MCAM, a member of the immunoglobulin superfamily of cell surface receptors, consists of the V-V-C2-C2-C2 Ig domains. It is a single chain glycoprotein with three mRNA splice variants. One has a short cytoplasmic tail, another has a long tail, and the third seems to lack transmembrane and cytoplasmic regions. It is highly homologous to gicerin, a molecule involved in neurite outgrowth and Wilm’s kidney tumor progression in the chicken, and to the human melanoma progression molecule MUC18. Chicken MCAM is expressed by c-kit hematopoietic progenitor cells in embryonic bone marrow, thymocytes, and capillary endothelial cells. MCAM-expressing cells sorted from bone marrow are enriched in progenitors capable of differentiating into T cells when transferred into the appropriate thymic microenvironment. MCAM has been proposed to be involved in cellular adhesion and homing processes.

Reactivity:

Chicken, Turkey

Host:

Mouse

Immunogen:

Mixture of E15 and E16 thymocytes from H.B15, H.B19, and H.B21 chicken embryos

Alternative Names:

CD146, HEMCAM, melanoma cell adhesion molecule

Conjugate:

PE (R-phycoerythrin)

Buffer :

Phosphate buffered saline containing < 0.1% sodium azide and a stabilizer

Clonality:

Monoclonal

Concentration:

0.1 mg/mL

Volume:

1.0 mL

Recommended Storage:

2-8°C, Avoid exposure to light, Do not freeze

Application:

Flow cytometry
Immunocytochemistry
Immunoprecipitation