Mouse anti Sheep Interleukin-8

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Mouse anti Sheep Interleukin-8
Products Name
Mouse anti Sheep Interleukin-8
Cat.No.
CBCA0058
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Overview

Description:
Mouse anti ovine interleukin-8 antibody, clone 8M6 recognizes ovine interleukin-8 (IL-8), also known as C-X-C motif chemokine 8. IL-8 is a 79 amino acid ~9-11 kDa chemoattractant for neutrophils, basophils and T-cells. IL-8 is produced by several cell types including neutrophils, monocytes and macrophages in response to inflammatory stimulation. Mouse anti ovine interleukin-8 antibody, clone 8M6 shows no cross-reactivity with ovine IL-1 beta, IL-6, MCP-1 or TNF alpha.

Responses to infectious stimuli may vary among ovine species, the response to Mannheimia haemolytica, a causative agent of pneumonia, peritonitis and gangrenous mastitis in ovids, is exaggerated in Bighorn sheep compared to domestic sheep with significantly elevated IL-8 levels in response to infection.

Mouse anti ovine interleukin-8 antibody, clone 8M6 has been utilized to identify cells and cell types expressing IL-8 in inflamed porcine tissue showing here also that neutrophils are the predominant cell type expressing IL-8 whilst epithelial and endothelial cells in the vicinity of inflammatory lesions also express the cytokine. Clone 8M6 neutralizes the bioactivity of ovine IL-8.
Mouse anti ovine interleukin-8 antibody, clone 8M6 has been used in conjunction with rabbit anti sheep Interleukin-8 antibody for the development of a sensitive ELISA to measure IL-8 concentrations in bovine samples.
Product Form:
Purified IgG - liquid.
Buffer :
Phosphate buffered saline.
Preservative Stabilisers:
<0.1% Sodium azide (NaN3).
Immunogen:
Recombinant bovine IL-8.
Approx. Protein Concentrations:
IgG concentration 1.0 mg/ml.
Regulatory:
For research purposes only.
Guarantee:
12 months from date of despatch.
Application:
ELISA, flow cytometry, functional assays, Western blotting.
Storage:
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Note:
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.
Product Type:
Monoclonal antibody
Clone:
8M6
Isotype:
IgG2a
Specificity:
IL-8
Species Cross-Reactivity:
Cat, bovine, dog, rabbit, horse, pig, ferret
Target:
Sheep

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