Mouse GIP Active ELISA
Products Name
Mouse GIP Active ELISA
Cat.No.
IVEK0231
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Overview
Product Overview:
This mouse GIP active ELISA is used for quantitative determination of mouse GIP (1-42) active form in plasma and culture medium supernatant. The kit is characterized by its sensitive quantification and high specificity. In addition, it has no influence by other components in samples. GIP (1-42) standard is highly purified synthetic product.
Product Description:
The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagons-like peptide-1 (GLP-1), are a group of gastrointestinal hormones that cause an increase in the amount of insulin released from the beta cells of the islets of Langerhans after ingestion of food.
The intestinal peptide GIP was first isolated from porcine upper small intestine1). The sequences of porcine, bovine and Mouse GIP have been determined, each has 42 amino acids, and the sequences is highly conserved. The porcine and bovine peptides differ from the Mouse at two and three site, respectively. Takeda et al. have isolated a Mouse cDNA encoding the GIP precursor and confirming that GIP belongs to the vasoactive intestinal peptide (VIP)/Glucagon/secretin family. GIP is a gastrointestinal peptide hormone that is released from duodenal endocrine K cells after absorption of glucose or fat7). GIP is a potent releaser of insulin in experimental animals and in man provided that the blood glucose is above basal level.
The intestinal peptide GIP was first isolated from porcine upper small intestine1). The sequences of porcine, bovine and Mouse GIP have been determined, each has 42 amino acids, and the sequences is highly conserved. The porcine and bovine peptides differ from the Mouse at two and three site, respectively. Takeda et al. have isolated a Mouse cDNA encoding the GIP precursor and confirming that GIP belongs to the vasoactive intestinal peptide (VIP)/Glucagon/secretin family. GIP is a gastrointestinal peptide hormone that is released from duodenal endocrine K cells after absorption of glucose or fat7). GIP is a potent releaser of insulin in experimental animals and in man provided that the blood glucose is above basal level.
Dynamic Range:
7.8 – 500 pg/mL
Incubation Time:
3.5 hours
Sample Type:
Cell culture supernates, plasma
Sample Size:
100 µl
