Recombinant Bovine Insulin-Like Growth Factor I
Products Name
Recombinant Bovine Insulin-Like Growth Factor I
Cat.No.
RBCA0008
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Overview
Description:
Recombinant bovine insulin-like growth factor I (IGF-I) is a recombinant protein corresponding to aa 50-119 of native bovine IGF-I.
IGF-I is a secreted mitogenic polypeptide and member of the insulin gene family, produced primarily by the liver, which effects a wide range of cells and plays a key role in cell proliferation and growth, inhibition of apoptosis, and is linked with tumor cell growth.
IGF-I signals by binding to the type 1 insulin-like growth factor receptor (IGF-IR) and also to the insulin receptor (IR), resulting in the activation of the AKT signaling pathway. IGF-I production is stimulated by growth hormone (GH) and can be hindered by GH insensitivity, deficiency in GH receptors or a malfunction in the post GH receptor signalling pathway.
IGF-I is a secreted mitogenic polypeptide and member of the insulin gene family, produced primarily by the liver, which effects a wide range of cells and plays a key role in cell proliferation and growth, inhibition of apoptosis, and is linked with tumor cell growth.
IGF-I signals by binding to the type 1 insulin-like growth factor receptor (IGF-IR) and also to the insulin receptor (IR), resulting in the activation of the AKT signaling pathway. IGF-I production is stimulated by growth hormone (GH) and can be hindered by GH insensitivity, deficiency in GH receptors or a malfunction in the post GH receptor signalling pathway.
Product Type:
Recombinant protein
Specificity:
IGF-I
Target:
Bovine
Product Form:
Purified recombinant protein - lyophilized.
Reconstitution:
Reconstitute with 20 μl sterile PBS containing 0.1% carrier protein.
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial.
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial.
Preparation:
Recombinant protein expressed in Pichia pastoris and purified by ion-exchange chromatography.
Buffer :
Phosphate buffered saline.
Preservative Stabilisers:
10% Trehalose.
Purity:
>95% by SDS PAGE analysis.
Protein Molecular Weight:
7.6 kDa.
Regulatory:
For research purposes only.
Guarantee:
12 months from date of despatch.
Application:
ELISA, western blotting.
Storage:
Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.
After reconstitution store at -20°C.
Note:
Storage in frost-free freezers is not recommended. This product should be stored undiluted.
