Porcine Immunoglobulin Antibodies

Immunoglobulins are heterodimeric proteins composed of two heavy chains (H) and two light chains (L), belonging to the eponymous immunoglobulin super-family (IgSF). By analyzing the amino acid sequences of the heavy and light chains of different immunoglobulins, it was found that the composition and arrangement of amino acid residues near the amino terminal (N-terminal) of the heavy and light chains vary greatly, and this region is called the variable region (V region), while the composition and arrangement of amino acid residues near the carboxyl terminal (C terminal) are relatively stable, so it is called the constant region (C region). Each V or C domain consists of about 110-130 amino acids, averaging 12,000-13,000 kDa. Each heavy and light chain of the immunoglobulin molecule can form a spherical domain by intra-chain disulfide bonds to perform its corresponding function, so it is also called the functional region. The heavy chain and light chain V region each form one structural domain, which is denoted as VH and VL respectively. The heavy chain and light chain C region form several structural domains with different numbers as follows: 1) γ, α and δ heavy chains form three structural domains, C_H1, C_H2 and C_H3; 2) μ and ε heavy chains form four structural domains, C_H1, C_H2, C_H3 and C_H4; 3) the light chain C region has only one structural domain, which is denoted as CL.

Figure 1. Two-dimensional model of an IgG molecule (Schroeder Jr, et al., 2010).

Porcine Immunoglobulin Antibodies

With the continuous development of porcine farming industry, a variety of porcine infectious diseases are prevalent in the porcine herd. These diseases can cause vomiting, diarrhea, fever and other symptoms in pigs, and even lead to death of porcine, which has caused serious economic losses to the porcine industry. The detection of immune responses caused by pathogens in porcine by antibodies is important for the diagnosis and control of infectious diseases in porcine. Currently, researchers have developed a series of antibodies to detect porcine immunoglobulins, which are suitable for use in ELISA, immunofluorescence, immunohistochemistry, flow cytometry, Western blotting, immunoprecipitation, etc.

BioVenic is a company that develops veterinary antibodies for the diagnosis of a wide range of animal diseases, with a state-of-the-art antibody development platform and professional technical staff. We can provide you with a range of polyclonal and monoclonal antibodies against porcine immunoglobulins. All of our antibodies have undergone rigorous testing and quality control, and have the advantages of high batch-to-batch consistency, high purity, and high specificity. If you have any needs, please feel free to contact us. We will provide you with high-quality products according to your needs.